When England's King Henry VIII wants to wage war with France, Cardinal Thomas Wolsey proposes a treaty that will ensure their place in history as the Duke of Buckingham plots to assert his own claim to the throne.
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In the wake of signing a treaty with France, Henry learns of Buckingham's plot to assassinate him as Lady Blount finally bears him the son he has always wanted.
Henry moves to cement his new alliance with Spain's Emperor Charles V as Anne Boleyn begins her seduction of the English king.
While passion sparks between Brandon and Princess Margaret as he escorts her to Portugal for her marriage to the king, and Norfolk and Sir Thomas conspire to discredit Wolsey, King Henry seeks to divorce Queen Katherine.
Resolved to marry Anne Boleyn, Henry presses Wolsey for a divorce; a betrayal of their treaty by Charles V sends Henry seeking a rapprochement with the French.
As Wolsey struggles to have the Church grant him a divorce, King Henry's infatuation with Anne Boleyn continues to grow.
As the plague that is sweeping England threatens Anne's life, Henry anxiously awaits word from the Pope regarding his request for a divorce.
The arrival of the Pope's envoy brings a decision on Henry's request for a divorce closer than ever.
As Wolsey is driven into exile as a result of the campaign waged by Norfolk and Boleyn, Henry turns to More to be his new chancellor.
As More begins his bloody campaign to cleanse England of heretics, the exiled cardinal Wolsey makes one last attempt to return to power.