At Oceanside Wellness, friendships are tested and secrets revealed when Addison discovers that Naomi is concealing the practice's financial problems. Meanwhile, Violet wonders what secret Cooper is keeping from her, while Cooper himself has to decide whether or not to reveal a medical secret to a patient.
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Addison and Sam form a hostile takeover in order to bring the practice out of bankruptcy, as all of the doctors look for additional clients and new income streams, while Violet's friendship with Cooper is on the brink of extinction and a married couple fight for an unethical fertility treatment at Oceanside Wellness.
Charlotte tries to woo Addison to St. Ambrose Hospital with promises of surgeries, as Addison and Kevin’s relationship heats up. Meanwhile Sam questions his ability to save Oceanside Wellness from financial ruin, Pete’s fire-fighter patient suffers an unusual form of post-traumatic stress disorder, and Violet is threatened by a patient’s son.
An office election pits Sam and Naomi against each other to lead the practice, and ends with surprising results, while Addison treats a young Afghan girl who wants to hide her past, and Cooper's objectionable personal life catches up with his professional one.
In trying to fix the financial troubles at Oceanside Wellness, Addison puts the practice in peril, as a good friend of Violet's places her in the terrible position of breaking the law to help her, and Maya hopes that her parents, Sam and Naomi, are rekindling their relationship for good.
Addison treats two pregnant women who unknowingly share the same husband, a visit from an Alzheimer's patient and her loving husband forces Sam and Naomi to look at their own relationship, Violet confronts Charlotte about her relationship with Cooper, and Dell reveals a very special woman in his life to his surprised co-workers.
Addison receives a surprise visit from her brother and fellow surgeon, Archer, and his presence not only causes trouble for her, but for Naomi and Sam as well. Meanwhile Meg returns to try to make it work with Pete, and a patient accused of a malicious crime stirs up anger and emotions, for both Violet and Dell.
Addison and Charlotte work together to save the lives of a pregnant woman in a coma and her unborn child, as Pete’s girlfriend, Meg, clashes with members of the Oceanside staff when she begins seeing patients there, and Violet seeks Kevin’s advice when a patient is suspected of murdering his wife.
Charlotte’s rival practice, Pacific Wellcare, opens its doors and the competition with Oceanside Wellness begins, as Sam and Pete steal one of their clients, a favourite patient of Addison’s goes to a Pacific Wellcare doctor for a second opinion, and Dell proposes the creation of an in-house adoption program.
Pete’s girlfriend, Meg, returns to Los Angeles and notices that Pete and Violet are considerably closer; Kevin questions the direction he and Addison are headed in as a couple; Cooper treats a young diabetic boy with a mysterious past; and Charlotte and her team of Pacific Wellcare doctors continue to siphon business away from Oceanside Wellness.
One of Cooper’s patients contracts the measles and forces the quarantine of all those at Oceanside Wellness, while Naomi pressures Addison into working with her cocky rival, Wyatt, on a fertility case; meanwhile, Violet and Pete wonder if their friends-with-benefits relationship should move to the next level, as Dell fights for sole custody of his daughter.
As Addison and Kevin struggle in their relationship, she finds herself attracted to Wyatt, the cocky doctor from rival Pacific Wellcare, while Violet seeks a way to carry on relationships with both Pete and Sheldon, and Cooper grows closer to Charlotte when she experiences a family emergency.
Violet finds out she's pregnant but isn't sure who the father is, Addison struggles with her own guilty conscience after her kiss with Wyatt, as Sam and Pete clash when an old friend and colleague asks them to help him die. Meanwhile Charlotte proposes marriage to Cooper
Addison's brother, Archer, moves to LA to begin work at Pacific Wellcare, causing problems for both her and Naomi, and Cooper encourages Violet to talk to Pete and Sheldon about her pregnancy, but she's reluctant when she learns that neither of them wants children.
When Archer suffers a severe seizure, his sister, Addison and his girlfriend, Naomi, aggressively search for the cause and cure, even calling Addison's ex-husband, Derek, for counsel. Meanwhile, Violet tells Sheldon and Pete that she is pregnant, and a seven year-old patient is abandoned, left for Cooper to care for.
As Archer recoups from surgery, Derek has Addison work with his pregnant neuro patient; after Sam suffers a sudden asthma attack, Bailey and Naomi work together to find the root cause of Sam’s sudden attack; and at Oceanside Wellness, Cooper, Violet and Pete work together to treat a mother suffering from post-partum depression.
As Naomi and Archer grow closer as a couple, Addison suspects that her brother may have returned to his old, bachelor ways. Meanwhile, Dell, Addison and Naomi heatedly debate the pros and cons of gender reassignment surgery when their patients’ newborn child is born with both male and female sex organs, and Violet and Sheldon settle some of their own issues when they co-lead a couples’ therapy group.
Addison is attracted to a colleague at St. Ambrose Hospital who turns out to be more than she bargained for; Pete and Sheldon team up to persuade Violet to take a paternity test, but she firmly resists their efforts; and Naomi helps Sam plan romantic activities with Sonya after he accidentally calls her "Naomi" in bed.
After Addison discovers that a mentally unbalanced pregnant patient has lost her baby, Violet must convince her that the baby has died and that surgery is necessary, while Cooper must tell a longtime patient he must remove part of his jaw due to a fast-growing cancer. Meanwhile, Dell copes with the absence of his daughter after his ex moves for a new job, and Sam and Addison find themselves suppressing their feelings for two very unattainable people.
Cooper struggles with a patient’s mother, who allows her twelve year-old daughter to be sexually active while Pete begins dating his patient’s fun and outgoing mother, creating a bit of jealousy in Violet; meanwhile, Sam must take the stand during a malpractice trial for a colleague and Addison continues to fight her feelings for a very persistent Noah.
When a pregnant woman starts to show signs of heart complications, Addison rushes her St. Ambrose where Noah is standing by to help. Meanwhile at Oceanside Wellness, Sam notices Naomi frequently sneaking away from the clinic, and her elusiveness causes him to rethink their friendship; Pete’s relationship with Lisa becomes complicated by Violet’s ever-present pregnancy; and Sheldon decides it’s time to take a stand.
As Violet chooses between Pete and Sheldon, a grief-stricken patient poses a danger to her; Addison faces her feelings for Noah as Morgan goes into labour; Dell has concerns for his daughter when a drugged-out Heather returns to town; and Naomi must decide if it’s in her best interest to stay with Oceanside Wellness or start anew at Pacific Wellcare.