At the invitation of her friend, fertility specialist Naomi Bennett, Addison leaves her job in Seattle and heads to Los Angeles to start a new job at Oceanside Wellness Group and to begin a new life. Not expecting Addison's arrival are Naomi's business partners at the co-op wellness center, her ex-husband, internist Sam Bennett, psychiatrist Violet Turner, paediatrician Cooper Freedman and alternative medicine guru Pete Wilder (who is convinced Addison is there because of their recent kiss). On her first day, Addison is presented a case that could make or break her acceptance among the Oceanside staff.
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Cooper hires an "entertainer" named Ginger for Sam as a way to jump start his new life as a single person, causing not only Naomi to become jealous, but Addison as well, after Ginger seeks Pete's help with a medical condition; and the Oceanside Wellness Group doctors and Saint Ambrose Hospital Chief of Staff Dr. Charlotte King work together to find the cause of a baby's illness.
Addison invites her fellow Oceanside Wellness co-workers to her house for a get-together, but no one RSVPs, the wife of Violet’s ex-boyfriend visits the wellness center for medical treatment-and Violet is none too happy about it-Cooper counsels a young patient who is lovesick, and Sam appears on his first talk show promoting his self-help book.
Addison must turn to Pete for help in treating a newlywed couple who can't consummate their marriage (no matter how much they try), while Violet tries to convince her patient to leave his wife, despite her own inability to move on from her ex, while Cooper investigates why his patients-four sisters-are all suffering from a mysterious illness.
Addison can’t stop thinking of Pete, despite the encouragement of her friends to channel her energy elsewhere; Allan, Violet’s ex, pays a visit to the clinic, and Cooper is not happy to see him; and Naomi and Sam’s daughter, Maya, secretly seeks Addison’s medical advice.
Charlotte seeks Pete’s help in treating her insomnia, Naomi goes on her first date since college, Cooper suspects that his patient’s injuries aren’t an accident, and a patient asks Addison and Naomi to conceal her fertility from her husband.
While Sam finds himself in the midst of a dangerous house call, love – or at least sex – is in the air at Oceanside Wellness Centre, as Pete and Addison decide to take their relationship to the next level, and Violet enters a "friends with benefits" pact with Cooper.
Cooper returns to the online dating game with surprising results, Addison goes out on a date with one of Violet’s patients, Naomi and Sam make a house call at a convent, Dell gives a tour of Oceanside Wellness to his midwifery classmates, and Addison and Pete participate in a "Safe Surrender" program, coming to the aid of a teenaged new mother.
The Oceanside Wellness Center takes on the fertility of one of their previous couples and starts a "Dads-to-be" class, much to Charlotte’s displeasure; Sam and Naomi struggle to figure out where their relationship is going; Addison is conflicted about her status in the dating world, and Cooper begins a secret affair with one of his colleagues.