Following his divorce from Julia, who is now living in New York with her two younger children, Sean sold his half of McNamara/Troy and departed Miami for Los Angeles. Having ended his engagement, Christian soon followed, thus relocating McNamara/Troy to the West Coast. Dr. Liz Cruz also joins the new McNamara/Troy for a fresh start, as she recovers physically and emotionally from past loves. In a city where they are professionally unknown, and where residents yearn for fame, Sean and Christian struggle for success.
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While a patient inspires Sean to take his relationship with Kate in a new direction, Eden uses extreme methods to persuade Christian to perform surgery on a friend. Kimber and Matt fall on hard times; as a result, Kimber reaches out to a former business associate.
As Sean tries to regain his youth through his relationship with Eden, a violent and traumatic event causes Julia to question her relationship with Olivia. Meanwhile, in an effort to better her life, Kimber makes a decision that devastates Matt.
After suspecting that something more than just their Secret Santa game is going on, Sean confronts Christian and Julia about the secret they have been keeping. Meanwhile, a hospitalized Matt bonds with his rehab counselor, and Eden tries to bond and make peace with Julia, which raises Julia's suspicions. Kimber reveals her plans for the future, and who is - and isn't - involved.
As Julia's health worsens, Christian falls back into old habits. Sean hires Gina as the new McNamara/Troy receptionist in order to get back at Christian. Meanwhile, Dawn Budge returns for cosmetic surgery after another unfortunate incident.
After Sean takes on an agent, his role on "Hearts 'n Scalpels" is expanded. Meanwhile, a suspicious Christian questions why Gina moved to Los Angeles and is working at McNamara/Troy, and what her motives might be.
Christian attempts to cope in the aftermath of a death. Meanwhile, Colleen feels threatened when another talent agency shows interest in Sean's acting career.
Eden looks to Sean for help after getting into business with Kimber and Ram. A group of wealthy socialites hires Christian for all of their cosmetic surgery needs. And Sean discovers another side of Colleen.
A television critic gives Sean a dose of the ugly side of Hollywood. Meanwhile, Matt experiences a special bond with one of Christian's patients. And the cause of Julia's ailing health is uncovered.
Tragedy strikes the McNamara/Troy family after Julia learns what has caused her ill health. A visitor from Christian's past brings some revealing news. And Sean finds the price of fame to be more expensive than it's worth.
Sean's physical and emotional well-being is greatly impacted after he survives the attack from Colleen. Meanwhile, Christian gets some troubling news.
Christian and Liz grow closer when his chemotherapy makes him ill and she becomes his caretaker. Sean reconnects with his broken family.
Sean tries to come to terms with his feelings for Julia. Christian meets someone who understands what he is going through. Plus, Liz and Christian analyze their relationship.
Matt gets jealous when Sean and Raj starts to develop a father/son relationship. Raj's father makes a surprise appearance. Plus, Christian and Liz try to make their relationship work.
Sean's hiring of a new anesthesiologist leads to trouble. Kimber goes to extreme measures to make sure Jenna has a good life.
Sean and Teddy explore their relationship and Christian relates to a patient with a unique condition.
Christian makes arrangements to secure his family's future after he's gone. Liz prepares for the wedding.
Christian searches for immortality as he prepares for his wedding. Kimber reacts to the news of Liz and Christian getting married.