As Henry VIII takes Jane Seymour as his third wife, a revolt against his brutal crackdown on Catholicism brews in the north.
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As the Pilgrimage of Grace gains support, King Henry dispatches Charles Brandon to the north in an effort to quell the uprising.
After promising to hear the rebels' grievances in exchange for an end to the revolt, Henry orders them mercilessly punished in an effort to quash dissent and preserve his hold on power.
While the violent suppression of the rebellion continues with the execution of its leaders, Henry prepares for the long-awaited birth of a son.
With Henry isolated in his grief over the death of his wife Jane, Cromwell worries that the hint of a breakdown in law and order signals more problems ahead for the Reformation.
As Henry's search for a new wife spreads across Europe, the execution of Pole's family threatens to plunge England into a war with France and Spain.
As a treaty between King Francis and Emperor Charles V spawns worries about an invasion of England, Henry's arranged marriage threatens to come undone after he meets his new bride, Anne of Cleves.
As Henry looks to dissolve his ill-advised marriage to Anne, behind the scenes Brandon paves the way for Cromwell's ultimate downfall.