Recent medical school graduate Emily Owens is now a first-year surgical intern at Denver Memorial Hospital and she is ready to leave high school persona of geeky-girl-with-flop-sweats behind her.
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Emily is oblivious to her bad reputation among the nurses until one of them presents her a with a very specific case as payback.
The surgical interns are presented with an impromptu medical quiz with a chance to assist in surgery as the prize, and Emily and Cassandra emerge as the winners.
Emily and Micah are scrambling to help a patient who desperately needs a kidney transplant, but they are confused when she turns down a kidney donation from her new husband.
Emily suffers a major embarrassment in front of her colleagues at the hands of a drug-impaired patient. In the aftermath, Emily decides to follow Dr. Bandari's advice and tries to toughen up.
mily provides some constructive criticism for Dr. Bendari on the attending evaluation form, but panics and tries to get the form back when she learns that Dr. Bendari reads the evaluations herself.
The hospital's popular flower delivery man collapses, and Emily sets out to diagnose his condition. However, she is confused by his refusal to accept treatment.
A female car accident victim is brought to the ER, and the staff immediately blames her boyfriend for causing the accident, which stirs some painful memories for Will.
Emily and Will work with a patient dressed as a costumed character, and though Will immediately assumes that the man's symptoms are caused a psychotic episode, Emily isn't so sure.
After a year away, Dr. A.J. Aquino returns to Denver Memorial. Before he is allowed to rejoin the staff, the Chief insists that he smooth things over with Dr. Bandari.
Emily, Will, and Cassandra are the final candidates for a research assistant position with Dr. Bandari, and feelings get hurt when Bendari asks them to describe one another's flaws.
The hospital is flooded with victims from a bus crash when a winter storm hits Denver, and Emily is assigned to run triage in the E.R.
Emily's decision about starting a relationship with Micah becomes even more complicated when Will hears about it and begins to feel jealous.