As Jack deals with a secret personal problem, drug-dealing terrorists threaten to release a virulent plague virus unless their leader is released from prison.
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Jack and the Salazars learn they have a rival in the auction for the virus; Chase is tortured by the Salazarsí men; Palmerís biggest campaign supporter orders him to fire Wayne; and Kim and Michelle realize Tony may not be fit for duty.
Jack returns Nina to the CTU, where Tony questions her; Jack is questioned by Internal Affairs; Kim confronts Chase about the baby; and Sherry tries to cover up her involvement after Millikenís death is discovered.
Jack finally catches Michael Amador, but only after Marcus Alvers has escaped with the virus and prepared to release it at a large hotel; and the police learn Sherry was at the Milliken mansion when Milliken died.
Jack learns the man behind the virus attacks is a former colleague of his; Saunders begins making demands on President Palmer; and Michelle and Tony begin accepting the fates of the infected people at the hotel.
When CTU agents use Saundersí daughter to help pinpoint his location, Saunders uses them to plan his escape; Michelle tests negative for virus exposure, but after Adamís sister tests positive, Chloe tries to convince Tony that Adam isnít able to function at his job.